Deregulated expression of PAX5 in medulloblastoma.

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Deregulated expression of PAX5 in medulloblastoma.

Medulloblatoma is a pediatric brain tumor originating in the human cerebellum. A collection of 23 medulloblastomas was analyzed for expression of the developmental control genes of the PAX and EN gene families by RNase protection and in situ hybridization. Of all nine PAX genes investigated, only PAX5 and PAX6 were consistently expressed in most medulloblastomas (70 and 78% of all cases, respec...

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PAX2 is a paired box transcription factor possessing a fundamental role in the embryogenesis of hindbrain and urinary tract. PAX genes are proto-oncogenes, PAX2 expression may contribute to the pathogenesis of renal cell carcinoma. Because of the expression of PAX2 in the developing hindbrain and its essential role in cerebellar development, it ha...

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PAX5 expression in nonhematopoietic tissues. Reappraisal of previous studies.

The Pax gene family encodes transcription factors with similar structures but distinctive roles in development and with limited expression in adult tissues. Reexpression of PAX proteins is frequently observed in human cancers, reflecting recapitulation of embryologic or developmental function. Defining expression of PAX family members is important in the immunohistochemical differential diagnos...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1995

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.92.12.5709